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SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.8
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
10 mcg (400 IU)
67%
Total Omega-3s♦
830 mg
†
EPA (Eicosapentaenoic Acid)
205 mg
†
DHA (Docosahexaenoic Acid)
480 mg
†
Top Medical Research Studies
7
Eicosapentaenoic acid showed mixed results
Improvement of coronary vasomotion with eicosapentaenoic acid does not inhibit acetylcholine-induced coronary vasospasm in patients with variant angina.
Study directly addresses chest pain
We examined how eicosapentaenoic acid (EPA), a key ingredient found in fish oil, impacts chest pain in patients with variant angina. Our study followed 22 individuals with this condition, where we infused acetylcholine, a substance known to cause coronary vasospasm, both before and after a four-month course of EPA treatment (1.8 g/day for 12 patients).
In the group that did not receive EPA, we observed no changes in how their coronary arteries responded to acetylcholine over time. However, for those treated with EPA, the results were quite intriguing. In non-spastic areas, the response shifted from vasoconstriction (narrowing) to vasodilation (widening). This indicates a notable improvement in how these arteries are functioning.
Yet, when it came to spastic sites where vasospasm had occurred, the coronary arteries remained responsive to acetylcholine, and the vasospasm persisted despite the EPA treatment. Thus, while EPA enhanced coronary responsiveness in some areas, it did not eliminate the acetylcholine-induced coronary vasospasms associated with variant angina.
In the group that did not receive EPA, we observed no changes in how their coronary arteries responded to acetylcholine over time. However, for those treated with EPA, the results were quite intriguing. In non-spastic areas, the response shifted from vasoconstriction (narrowing) to vasodilation (widening). This indicates a notable improvement in how these arteries are functioning.
Yet, when it came to spastic sites where vasospasm had occurred, the coronary arteries remained responsive to acetylcholine, and the vasospasm persisted despite the EPA treatment. Thus, while EPA enhanced coronary responsiveness in some areas, it did not eliminate the acetylcholine-induced coronary vasospasms associated with variant angina.
Read More
8
Eicosapentaenoic acid may reduce chest pain
[Study of in vitro thromboxane A2 generation by platelets of patients with first-time appearing angina pectoris under the effect of fish diet].
Moderate relevance in dietary effects
We explored how an eicosapentaenoic acid (EPA)-rich diet influences the generation of thromboxane A2 (TxA2) in patients experiencing first-time angina pectoris. TxA2 plays a crucial role in promoting blood clotting and causing spasms of the blood vessels, both of which are key issues in coronary heart diseases.
Our study compared the effects of an EPA-rich diet with a standard hospital diet on the ability of platelets to generate TxA2 when stimulated by ADP. Among the 12 patients with first angina, those who adhered to the standard hospital diet showed the capacity to produce TxA2 under these conditions. Conversely, those who consumed the EPA-rich diet did not exhibit this same generation of TxA2.
The findings suggest that the fish-based diet rich in EPA may positively affect platelet aggregation. We observed a reduced potential for harmful TxA2 generation in the patients on the EPA-rich diet, indicating a possible lower risk for vascular spasms associated with angina.
In conclusion, while more research is needed to confirm these effects, the initial results reveal that incorporating EPA into the diet might help alleviate some risks associated with chest pain due to its impact on platelet behavior.
Our study compared the effects of an EPA-rich diet with a standard hospital diet on the ability of platelets to generate TxA2 when stimulated by ADP. Among the 12 patients with first angina, those who adhered to the standard hospital diet showed the capacity to produce TxA2 under these conditions. Conversely, those who consumed the EPA-rich diet did not exhibit this same generation of TxA2.
The findings suggest that the fish-based diet rich in EPA may positively affect platelet aggregation. We observed a reduced potential for harmful TxA2 generation in the patients on the EPA-rich diet, indicating a possible lower risk for vascular spasms associated with angina.
In conclusion, while more research is needed to confirm these effects, the initial results reveal that incorporating EPA into the diet might help alleviate some risks associated with chest pain due to its impact on platelet behavior.
Read More
8
Eicosapentaenoic acid shows potential
The long-term effect of dietary supplementation with fish lipid concentrate on serum lipids, bleeding time, platelets and angina.
Study relevant, lacks control comparison.
We examined the impact of eicosapentaenoic acid—a key component in fish oil—on chest pain among 107 individuals over two years. Ninety-two of these participants had established heart disease or high cholesterol levels, while 15 did not have any history of heart problems.
Through this study, we found that serum triglyceride levels dropped quickly, suggesting a significant benefit for those dealing with high fat in the blood. While cholesterol levels decreased at a slower rate, intriguingly, the levels of good cholesterol (HDL) increased—often associated with better heart health.
Another notable finding was the lengthening of bleeding times and a reduced need for glyceryl trinitrate (GTN) tablets, which are often used to relieve angina attacks. This reduction in angina suggests that eicosapentaenoic acid might help alleviate chest pain by lowering the frequency of angina episodes and affecting platelet behavior, making them less likely to clump together.
However, it is essential to point out that while these changes promote heart health, this study did not compare the fish lipid concentrate with a placebo or an alternative treatment, leaving some of the isolated effects a little unclear. Overall, the trends observed are promising for heart disease management but should be interpreted with caution.
Through this study, we found that serum triglyceride levels dropped quickly, suggesting a significant benefit for those dealing with high fat in the blood. While cholesterol levels decreased at a slower rate, intriguingly, the levels of good cholesterol (HDL) increased—often associated with better heart health.
Another notable finding was the lengthening of bleeding times and a reduced need for glyceryl trinitrate (GTN) tablets, which are often used to relieve angina attacks. This reduction in angina suggests that eicosapentaenoic acid might help alleviate chest pain by lowering the frequency of angina episodes and affecting platelet behavior, making them less likely to clump together.
However, it is essential to point out that while these changes promote heart health, this study did not compare the fish lipid concentrate with a placebo or an alternative treatment, leaving some of the isolated effects a little unclear. Overall, the trends observed are promising for heart disease management but should be interpreted with caution.
Read More
Most Useful Reviews
8.8
Chest pain relief
I began taking omega after seeing positive reviews. I didn't anticipate such results; previously, I experienced chest pain, but after using omega, the discomfort in my lower abdomen disappeared, and there was no tonus detected in my second ultrasound. Omega also aids in the baby's brain development and overall well-being. I'm delighted that the tightness in my skin has vanished. I will continue taking omega throughout my pregnancy and for gut health.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.8
8
Vitamin D3's Heart Impact
Non-invasive quick diagnosis of cardiovascular problems from visible and invisible abnormal changes with increased cardiac troponin I appearing on cardiovascular representation areas of the eyebrows, left upper lip, etc. of the face & hands: beneficial manual stimulation of hands for acute anginal chest pain, and important factors in safe, effective treatment.
Limited impact on chest pain
We explored how vitamin D3 plays a role in managing chest pain, particularly in relation to various cardiovascular health indicators. Our investigation emphasizes the significance of optimal vitamin D3 dosage; notably, 400 IU proves beneficial for heart health. However, we also highlighted the potential risks associated with higher doses, such as the commonly used 2000 IU, which can be detrimental.
While vitamin D3 shows promise for overall wellness, its direct impact on alleviating chest pain remains less clear. The study examines visible and invisible changes on the face that suggest cardiovascular issues, with a focus on areas like the eyebrows and left upper lip. However, there’s no conclusive evidence to suggest a marked improvement in chest pain solely from vitamin D3 treatment.
Overall, while maintaining adequate vitamin D3 levels is crucial for heart health, relying on it exclusively to relieve chest pain doesn't seem fully supported by our findings. The emphasis is on a comprehensive approach, combining dietary supplements with other medical interventions for heart conditions.
While vitamin D3 shows promise for overall wellness, its direct impact on alleviating chest pain remains less clear. The study examines visible and invisible changes on the face that suggest cardiovascular issues, with a focus on areas like the eyebrows and left upper lip. However, there’s no conclusive evidence to suggest a marked improvement in chest pain solely from vitamin D3 treatment.
Overall, while maintaining adequate vitamin D3 levels is crucial for heart health, relying on it exclusively to relieve chest pain doesn't seem fully supported by our findings. The emphasis is on a comprehensive approach, combining dietary supplements with other medical interventions for heart conditions.
Read More
8
Calcium and vitamin D3 treatment effective
ECG changes in a 25-year-old woman with hypocalcemia due to hypoparathyroidism. Hypocalcemia mimicking acute myocardial infarction.
Adjusted relevance score due to combination treatment
We explored the case of a 25-year-old woman who experienced chest pain and ECG changes typically associated with a heart attack. After undergoing cardiac catheterization, doctors found her coronary arteries to be normal but noted impaired left ventricular performance.
Further tests revealed she had primary hypoparathyroidism leading to low calcium levels, or hypocalcemia. To address this, she was treated with calcium and vitamin D3 supplements, which significantly improved her condition and alleviated her symptoms.
Although she eventually remained symptom-free, some ECG repolarization disturbances persisted. This case provides important insights into how low calcium levels can mimic acute myocardial infarction and highlights the effective role of vitamin D3 and calcium in alleviating related chest pain.
Further tests revealed she had primary hypoparathyroidism leading to low calcium levels, or hypocalcemia. To address this, she was treated with calcium and vitamin D3 supplements, which significantly improved her condition and alleviated her symptoms.
Although she eventually remained symptom-free, some ECG repolarization disturbances persisted. This case provides important insights into how low calcium levels can mimic acute myocardial infarction and highlights the effective role of vitamin D3 and calcium in alleviating related chest pain.
Read More
8
Eicosapentaenoic acid’s effects inconclusive
Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival--4.
Limited relevance to chest pain
We conducted a randomized, double-blind, placebo-controlled trial to assess how eicosapentaenoic acid, found in fish oil, might impact chest pain in patients experiencing suspected acute myocardial infarction (AMI). Over one year, we compared outcomes among groups taking fish oil, mustard oil, and a placebo, all starting treatment roughly 18 hours after symptoms appeared.
Our findings highlighted that both fish oil and mustard oil groups experienced fewer overall cardiac events compared to the placebo group. However, while we did observe reductions in nonfatal infarctions and total cardiac deaths within the fish oil group, there was no similar reduction in chest pain or direct measures of angina specifically linked to these treatments.
Interestingly, the study indicated that levels of cardiac arrhythmias and left ventricular enlargement were also reduced in those taking fish oil and mustard oil compared to those on a placebo. While we saw some improvements in overall cardiac health, the direct effects on chest pain from taking eicosapentaenoic acid were not conclusively established in this trial.
Ultimately, although fish oil shows promise in improving various heart-related outcomes, the specific impact on chest pain wasn't distinctly proven through our study results. Further extensive research will be essential to draw firmer conclusions.
Our findings highlighted that both fish oil and mustard oil groups experienced fewer overall cardiac events compared to the placebo group. However, while we did observe reductions in nonfatal infarctions and total cardiac deaths within the fish oil group, there was no similar reduction in chest pain or direct measures of angina specifically linked to these treatments.
Interestingly, the study indicated that levels of cardiac arrhythmias and left ventricular enlargement were also reduced in those taking fish oil and mustard oil compared to those on a placebo. While we saw some improvements in overall cardiac health, the direct effects on chest pain from taking eicosapentaenoic acid were not conclusively established in this trial.
Ultimately, although fish oil shows promise in improving various heart-related outcomes, the specific impact on chest pain wasn't distinctly proven through our study results. Further extensive research will be essential to draw firmer conclusions.
Read More
8
Eicosapentaenoic acid may reduce chest pain
[Study of in vitro thromboxane A2 generation by platelets of patients with first-time appearing angina pectoris under the effect of fish diet].
Moderate relevance in dietary effects
We explored how an eicosapentaenoic acid (EPA)-rich diet influences the generation of thromboxane A2 (TxA2) in patients experiencing first-time angina pectoris. TxA2 plays a crucial role in promoting blood clotting and causing spasms of the blood vessels, both of which are key issues in coronary heart diseases.
Our study compared the effects of an EPA-rich diet with a standard hospital diet on the ability of platelets to generate TxA2 when stimulated by ADP. Among the 12 patients with first angina, those who adhered to the standard hospital diet showed the capacity to produce TxA2 under these conditions. Conversely, those who consumed the EPA-rich diet did not exhibit this same generation of TxA2.
The findings suggest that the fish-based diet rich in EPA may positively affect platelet aggregation. We observed a reduced potential for harmful TxA2 generation in the patients on the EPA-rich diet, indicating a possible lower risk for vascular spasms associated with angina.
In conclusion, while more research is needed to confirm these effects, the initial results reveal that incorporating EPA into the diet might help alleviate some risks associated with chest pain due to its impact on platelet behavior.
Our study compared the effects of an EPA-rich diet with a standard hospital diet on the ability of platelets to generate TxA2 when stimulated by ADP. Among the 12 patients with first angina, those who adhered to the standard hospital diet showed the capacity to produce TxA2 under these conditions. Conversely, those who consumed the EPA-rich diet did not exhibit this same generation of TxA2.
The findings suggest that the fish-based diet rich in EPA may positively affect platelet aggregation. We observed a reduced potential for harmful TxA2 generation in the patients on the EPA-rich diet, indicating a possible lower risk for vascular spasms associated with angina.
In conclusion, while more research is needed to confirm these effects, the initial results reveal that incorporating EPA into the diet might help alleviate some risks associated with chest pain due to its impact on platelet behavior.
Read More
8
Eicosapentaenoic acid shows potential
The long-term effect of dietary supplementation with fish lipid concentrate on serum lipids, bleeding time, platelets and angina.
Study relevant, lacks control comparison.
We examined the impact of eicosapentaenoic acid—a key component in fish oil—on chest pain among 107 individuals over two years. Ninety-two of these participants had established heart disease or high cholesterol levels, while 15 did not have any history of heart problems.
Through this study, we found that serum triglyceride levels dropped quickly, suggesting a significant benefit for those dealing with high fat in the blood. While cholesterol levels decreased at a slower rate, intriguingly, the levels of good cholesterol (HDL) increased—often associated with better heart health.
Another notable finding was the lengthening of bleeding times and a reduced need for glyceryl trinitrate (GTN) tablets, which are often used to relieve angina attacks. This reduction in angina suggests that eicosapentaenoic acid might help alleviate chest pain by lowering the frequency of angina episodes and affecting platelet behavior, making them less likely to clump together.
However, it is essential to point out that while these changes promote heart health, this study did not compare the fish lipid concentrate with a placebo or an alternative treatment, leaving some of the isolated effects a little unclear. Overall, the trends observed are promising for heart disease management but should be interpreted with caution.
Through this study, we found that serum triglyceride levels dropped quickly, suggesting a significant benefit for those dealing with high fat in the blood. While cholesterol levels decreased at a slower rate, intriguingly, the levels of good cholesterol (HDL) increased—often associated with better heart health.
Another notable finding was the lengthening of bleeding times and a reduced need for glyceryl trinitrate (GTN) tablets, which are often used to relieve angina attacks. This reduction in angina suggests that eicosapentaenoic acid might help alleviate chest pain by lowering the frequency of angina episodes and affecting platelet behavior, making them less likely to clump together.
However, it is essential to point out that while these changes promote heart health, this study did not compare the fish lipid concentrate with a placebo or an alternative treatment, leaving some of the isolated effects a little unclear. Overall, the trends observed are promising for heart disease management but should be interpreted with caution.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Chest pain relief
I began taking omega after seeing positive reviews. I didn't anticipate such results; previously, I experienced chest pain, but after using omega, the discomfort in my lower abdomen disappeared, and there was no tonus detected in my second ultrasound. Omega also aids in the baby's brain development and overall well-being. I'm delighted that the tightness in my skin has vanished. I will continue taking omega throughout my pregnancy and for gut health.
Read More
